Potential Blockbuster Hyperkalemia Drug, And Mast...

This week examines significant developments from biotech companies AstraZeneca (AZN), Relypsa (RLYP), and Mast Therapeutics (MSTX). AZN deserves investor attention because on May 26th, 2016 the FDA rejected its potential blockbuster hyperkalemia drug, ZS-9, citing concerns over its pre-manufacturing process. More specifically, the FDA issued a complete response letter (CRL) and 483 form to AZN, which states a drug will not be approved in its current state, but does not require new clinical data for potential future approval. This came as a surprise to many who expected a smooth road to approval for ZS-9 after AZN purchased ZS Pharma for $2.7 billion last December. AZN shares were only down 1% as a result of the news, but competitor RLYP saw its shares jump ≈29%. Previously, a general market consensus had arisen that AZN would swoop in with a superior drug and claim most of the market for hyperkalemia, but with the FDA’s denial of ZS-9 that future looks murkier. This surp rising catalyst provides an excellent opportunity to interview an expert about the long term effect this will have on the hyperkalemia landscape and what the future looks like for both AZN and RLYP. MSTX warrants investor interest after their CEO announced they would be delaying the release of Phase 3 top-line data for EPIC (using vepoloxamer to treat sickle cell disease) by more than a month due to delays locking their patient dataset. Despite this announcement, MSTX’s stock price has risen more thanShow MoreRelatedImpact Of Biotechnology On The Stock s Potential1921 Words   |  8 Pagesbiotech companies AstraZeneca (AZN), Relypsa (RLYP), and Mast Therapeutics (MSTX) where recent FDA and management announcements have the potential to significantly impact the stock’s potential. In both scenarios below, speaking to an expert will help investors gain insights into these complex situations and perform fundamental diligence. AZN deserves investor attention as the FDA recently rejected its potential blockbuster hyperkalemia drug, ZS-9, citing concerns over its pre-manufacturing process

The Necklace By Guy De Maupassant - 1019 Words

In the short story of â€Å"The Necklace†, the author Guy de Maupassant is a creative and intriguing tale which reveals a person s dreams of a luxurious lifestyle with countless materialistic possessions. He has skillfully developed the story into a mystery which reveals itself at the end. The main point in the story is that materialism can distort your view of happiness and fulfillment. It is wrong to be materialistic to the extent that you disregard what you already have and lose everything. Mathilde Loisel, a character who dreams of riches, but at the expense of losing everything else. She is discontent with the life she leads as the wife of a humble clerk who cannot afford the luxuries she wants. According to the Jessica Krehlik, she describes Mathlide s surroundings, but as a writer felt that this one meant more, because it was actually something that even she wasn t actually able to see--only imagine by saying She suffered from the poorness of her house, from its mean wa lls, worn chairs, and ugly curtains. All these things, of which other women of her class would not even have been aware, tormented and insulted her.† Literally that was exactly the way Mathilde was feeling with the kind of life she was having. In addition, the author described the settings of the apartment reflecting on Mathilde s unhappiness; for instance, he compared the drab walls with Mathilde s plain and monotonous life, the shabby furniture with her feelings of living like aShow MoreRelatedThe Necklace By Guy De Maupassant863 Words   |  4 PagesThe short story â€Å"The Necklace† written by Guy De Maupassant, tells the story of a married couple who live an average lifestyle together in France—when one day everything in their lives changes due to a simple decision. The author aims to show the reader the power of decision making when faced to decide between needs, wants, honesty and untruthfulness and how every decision we choose to make affect our lives in ways we never thought possible. In the first few lines of the story, the narrator introducesRead MoreThe Necklace by Guy de Maupassant1034 Words   |  5 Pagesregret which Guy de Maupassant depicts throughout â€Å"The Necklace.† Guy de Maupassant, a French writer, born in 1850, was considered one of France’s greatest short-story writers. His writings were mostly influenced by the divorce of his parents when he was thirteen years old and by great writers such as Shakespeare, Schopenhauer, and Flauber. His parent’s divorce caused his stories to depict unhappiness of matrimony, deceit, miscommunication, and a profound misunderstanding (Maupassant, Guy de, 1850-1893)Read MoreThe Necklace by Guy De Maupassant1367 Words   |  6 Pagesâ€Å"Being Honest is Always Best† Telling the truth will always prevent future conflicts. Author Guy De Maupassant who lived from 1850 to 1893 proves in the story of â€Å"The Necklace,† that no matter how bad a situation is, speaking with the truth is always best. Now, this author does not prove this theme directly. Instead, throughout various situations in the story the main characters are faced with a long-term conflict because decisions were not made with honesty. Mathilde and Loisel who is her husbandRead MoreThe Necklace, by Guy de Maupassant791 Words   |  4 Pagescharacterized by other people. In â€Å"The Necklace† Mme. Loisel is a beautiful woman with a decent life, and a husband that loves her, and only wants to make her happy. She is not rich but she makes it along, she insists of a better, wealthier life. When her husband gets her invited to a ball, she feels the need for a brand new fancy dress and tons of jewelry. When the couple realizes they cannot afford jewelry as well, they searc h out to borrow her friend, Mme. Forestiers’ necklace. She comes to notice she noRead MoreThe Necklace, By Guy De Maupassant966 Words   |  4 PagesIn Guy De Maupassant’s â€Å"The Necklace,† Mathilde is a 19th century French woman who desires a wealthier lifestyle than she can acquire. She is completely indulged in the material possessions of life and is focused on the items she does not have rather than what she owns. It seems her happiness is entirely dependent on wealth and status. She neglects her husband and is never content with what he can offer. Eventually, Mathilde’s struggles of envy, selfishness, and materialism drive her to poverty.Read MoreThe Necklace By Guy De Maupassant934 Words   |  4 Pagesduring this time period was Guy de Maupassant, who wrote one of the most influential short stories of this century. â€Å"The Necklace†, written by Guy de Maupassant, illustrates elements of fiction such as the symbolism of the necklace be cause of Mme. Loisel’s desire to be rich, irony due to the twist ending, and a powerful theme. Firstly, the necklace Mme. Loisel borrows and her perspective symbolizes the desire she has towards being wealthy and important in society. Maupassant describes effectively theRead MoreThe Necklace By Guy De Maupassant1381 Words   |  6 Pagesstories are â€Å"The Necklace† by Guy de Maupassant and â€Å"The Secret Life of Walter Mitty† by James Thurber. â€Å"The Necklace† was about a materialistic woman who faced consequences because of her envious personality and â€Å"The Secret Life of Walter Mitty† was about a man who experienced daydreams randomly throughout the day. Although both short stories used literary elements, Guy de Maupassant utilized them for readers to understand and enjoy the story more than James Thurber. â€Å"The Necklace† was a short storyRead MoreThe Necklace By Guy De Maupassant1093 Words   |  5 PagesThroughout the short story titled â€Å"The Necklace† by Guy de Maupassant, it is clear that the main themes being stressed are pride versus greed, and that things are not quite what they appear. Each of these things are represented throughout the story in some way, whether it be using animated language or symbolism. It is also clear that background information clearly aided the development of the themes Maupassant incorporated throughout the passage. It is seen throughout the story that the main characterRead MoreThe Necklace, By Guy De Maupassant999 Words   |  4 PagesIn Guy de Maupassant’s â€Å"The Necklace,† readers experience Mathilde Loisel’s life-changing event. Coming from nobility, de Maupassant tells the story of luxurious desire through the eyes of the middle class woman Mathilde. Mathilde constantly dreams of living the life of the upper class, and this prohibits her from acting in reality. Mathilde’s internal struggle for a sense of social royalty shows readers how quickly selfish pride destroys a person’s life. Throughout the course of â€Å"The NecklaceRead MoreThe Necklace, By Guy De Maupassant823 Words   |  4 Pagesbe totally unhappy, â€Å"She was a simple person without the money to dress well, but she was as unhappy as if she had gone through bankruptcy, for a woman have neither rank nor race†(Maupassant 7). Loisel s sorrow over wealth and fancy things puts a constant pain on her husband. In Guy de Maupassant short story â€Å"The Necklace,† Mathlide Loisel goes from being a materialistic, dishonest woman to becoming an honest, hard-working woman. At the beginning of the story, Mathlide Loisel is a raging, spoiled

Because I Could Not Stop for Death Emily Dickenson Free Essays

Miranda Jennifer Professor A. Tripp English 355 1, October 2012 Loss Is Nothing Else but Change Experiencing a loss raises overwhelming feelings that are difficult to cope with. The emotions that accompany any kind of loss can be intense and varied. We will write a custom essay sample on Because I Could Not Stop for Death Emily Dickenson or any similar topic only for you Order Now There are stages of grief that everyone goes through. A sense of shock or denial usually come first followed by anger. Bargaining follows anger, then depression, and finally acceptance. In â€Å"Because I Could Not Stop for Death,† by Emily Dickinson, the speaker is taken on an un expected journey that illuminates her path of mourning, which helps her come to an acceptance with her loss. The title: â€Å"Because I Could Not Stop for Death,† states that the speaker could not begin to grieve the loss. The speaker knew it had to end but could not bear to end it on his of her own, thus â€Å"Because I could not stop for Death,/ He kindly stopped for me;†(Lines 1-2). Dickinson mentions the speaker’s outfit as a symbolism of unpreparedness. â€Å"For only gossamer my gown/ my tippet only tulle,† (15-16). Dickinson’s word choice play a vital role throughout the poem. The term â€Å"immortality†(4) signifies that the journey would never end. The speaker is well aware that the journey embarked on was not a round trip. The speaker is taken on a journey filled with many experiences, all which he or she accepts and learns from. This journey illuminated the speaker’s perspective of grieving with the loss of something or someone. According to Oxford Dictionaries, the adjective illuminating can be defined as: â€Å"to help to clarify or explain† (Illuminate). Even though the journey was unexpected, it brought enlightenment to the speaker’s perspective of his or her loss. People feel pain when going through a loss, but in â€Å"Because I Could Not Stop for Death,† the speaker accepts it with ease, â€Å"I had put away/ My labor, and my leisure too,/ For his civility†(6-8). The speaker is essentially relieved concerning the loss. He or she is finally able to forget about everything that worries him or her. Overall, the loss brought the speaker tranquility. In stanza three, the speaker takes a trip down memory lane. â€Å"We passed the school, where children strove At recess, in the ring; We passed the fields of gazing grain, We passed the setting sun. † Remembering past times is a typical thing to do when dealing with grief. The speaker of â€Å"Because I Could Not Stop for Death,† accepted his or her loss, for it eventually led her to an immortally full of bliss. When losing someone or something, it is important to know that it will get better. Losing someone or something can be the most devastating thing for anyone, but it is important to understand that once you come to acceptance with the loss, there is light behind the tunnel. The speaker of the poem is well aware of this and he or she agrees to the journey, not knowing where his or her destination would be. After a long journey of mourning, the speaker is taken to a new home, where he or she can finally be at ease. â€Å"We paused before a house [†¦]/ The roof was scarcely visible,†(7,9). A new home signifies a new beginning. Over all the loss that the speaker is going through, has brought him or her to a new commencement in his or her life. â€Å"’Tis centuries, and yet each Feels shorter than the day I first surmised the horses’ heads Were toward eternity. † The best thing one can do when moving on from a loss is to take each passing moment as an opportunity to grow. The speaker was able to view his or her loss as an opportunity for emotional growth. Thus, the journey that the speaker in â€Å"Because I Could Not Stop for Death† took illuminated his or her path towards the acceptance of his or her loss. Marcus Aurelius said, â€Å"Loss is nothing else but change, and change is Nature’s delight. † Works Cited Dickinson, Emily. â€Å"Because I Could Not Stop for Death. † The Compact Bedford Introduction to Literature: Reading, Thinking, Writing. 9th ed. Ed. Michael Meyer. Boston: Bedford/St. Martins, 2012. 844. Print. â€Å"Illuminate. † Definition of Illuminate. Oxford Dictionaries, 2012. Web. 24 Sept. 2012. . Meyer, Michael. â€Å"A Study of Emily Dickinson. † Preface. The Compact Bedford Introduction to Literature: Reading, Thinking, Writing. 9th ed. Boston: Bedford/St. Martins, 2012. 819-28. Print. How to cite Because I Could Not Stop for Death Emily Dickenson, Papers